腹腔神经丛阻滞术治疗晚期胰腺癌顽固性疼痛的临床研究

目的 观察无水乙醇腹腔神经丛阻滞术对晚期胰腺癌顽固性疼痛的镇痛效果、并发症发生及患者生存质量的影响。方法 选取2001年1月至2005年9月61例晚期胰腺癌伴顽固性疼痛及消化道梗阻无法行根治手术的患者，在行姑息性手术的同时，行腹腔神经丛无水乙醇阻滞治疗，观察术后3个月内疼痛缓解、生存质量评分（KPS）的变化及不良反应。结果 治疗后1周内全部患者顽固性疼痛症状明显缓解（P〈0．05），KPS评分显著提高（P〈0．05）。随诊3个月，术后86．5％（45／52）患者无痛或仅轻度疼痛，治疗过程中和治疗后未发生严重并发症。结论 无水乙醇腹腔神经丛阻滞治疗晚期胰腺癌顽固性疼痛能较好地缓解其症状，改善患者生存质量，近期疗效确切，安全性高。

Intra-Abdominal Coeliac Plexus Block to Treat Unresectable Pancreatic Cancer Pain

Objective The effects and the complications of anhydrous alcohol intra-abdominal coeliac plexus block were studied for treating unresectable pancreatic cancer pain. Methods From Jan.2001 to Sep.2005, 61 patients with severe pancreatic cancer pain and accompanied gastrointestinal tract obstruction were treated by anhydrous alcohol intra-abdominal coeliac plexus block and palliative surgical therapy. Pain-relief, KPS and complications in 3 months after operation were observed. Results The cancer pain in all patients was controlled in one week after the block (P<0.05). KPS was improved (P<0.05). Three months after operation, 45(86.5%) patients were without pain or with only light pain. There were no severe complications. Conclusion Anhydrous alcohol intra-abdominal coeliac plexus block is a method with safe and good effective and less complications for the treatment of pancreatic carcinomatous pain.