清下消补法组方对乙肝肝硬化预后因素影响的临床观察

目的：以预后因素为评定指标观察中医药清下消补法为主辨证施治配合西医药对乙肝肝硬化的疗效。方法：本研究设研究组和对照组，两组患者均为30人。为保持组间均衡性，本研究采用匹配对照设计，匹配依据为王吉耀肝硬化8项预后因素。结果：研究组除血红蛋白(Hb)外，血清总胆红素(TBIL)、血清白蛋白(ALB)、凝血酶原时间(PT)等预后因素统计学差异均显著，腹水、肝性脑病、上消化道出血疗效显著；组间对比统计分析只有血清总胆红素有统计学差异。结论：1．本研究提示中医药清下消补法为主辨证施治配合西医药治疗对乙肝肝硬化预后因素有积极影响。2．中医药清下消补法辨证施治治疗乙肝肝硬化退黄疗效显著。

Clinical Observations on Effects on Prognostic Factor Treating Hepatitis B-related Cirrhosis with Purification Purgation Dispersion Tonicity

OBJECTIVE: With prognostic factors as assessment standards, the effects of combination of TCM(purification purgation dispersion tonicity) and western medicine treating hepatitis B-related cirrhosis and its complications were assessed. METHODS: In this study, study group and control group were divided, the number of each group was 30. In order to keep balance between the two groups, matching control design was adopted with Wang's 8 prognostic factors as matching conditions. RESULTS: In study group, except Hb, TBIL, ALB and PT had statistic difference, and the complications of cirrhosis such as ascites, HEP and UGH were treated with significant effects. Between study group and control group, in all of prognostic factors only TBIL had statistical diffirence. CONCLUSIONS: It suggested the effects were significant treating hepatitis B-related cirrhosis and its complications with combination of TCM(purification purgation dispersion tonicity) and western medicine. It also suggested that TCM therapy combining purification, purgation, dispersion and tonicity had significant effects on reducing jaundice.