| 新型共刺激分子B7-H4在肿瘤免疫中的研究进展 |
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| 引用本文： | 陶岚. 新型共刺激分子B7-H4在肿瘤免疫中的研究进展[J]. 国际免疫学杂志, 2009, 32(1): 20-24. DOI: 10.3760/cma.j.issn.1673-4394.2009.01.006 |
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| 作者姓名： | 陶岚 |
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| 作者单位： | 浙江大学免疫学研究所,杭州,310058 |
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| 基金项目： | 国家重点基础研究发展规划(973计划) |
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| 摘 要： | B7-H4是共刺激分子B7家族的最新成员，是B7家族相关的第3个T细胞抗原特异性反应的负性调控分子，在CD4^＋、CD8^＋T细胞的分化发育、细胞周期的进展以及细胞因子的产生方面发挥广泛的抑制效应。B7-H4途径在器官特异性自身免疫病、病毒感染、移植耐受和肿瘤免疫逃避等方面可能具有重要的作用，因而对B7-H4在肿瘤免疫逃避中发挥的作用的深人研究可以为肿瘤的生物学诊断及治疗策略提供一个新的方向。
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| 关 键 词： | B7-H4 肿瘤免疫 肿瘤免疫逃避机制 |
Recent progress in the study on the functions of the novel costimulatory molecule B7-H4 in tumor immunity |
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| TAO Lan. Recent progress in the study on the functions of the novel costimulatory molecule B7-H4 in tumor immunity[J]. International Journal of Immunology, 2009, 32(1): 20-24. DOI: 10.3760/cma.j.issn.1673-4394.2009.01.006 |
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| Authors: | TAO Lan |
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| Affiliation: | TAO Lan( Institute of lmmunology,Zhejiang University,Hangzhou 310058,China) |
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| Abstract: | B7-H4,the newest member of costimulating molecules B7 family,is the third negative regulator of Antigen-specific T cell responses by extensive inhibiting CD4+ and CD8+T cells proliferation,cell cycle progression,and cytokine production.Researches demonstrated that B7-H4 pathway may play important role in organ-specific autoimmune diseases,viral infection,transplantation tolerance,and tumor immune escape.Profound studies of B7-H4 in tumor immune escape may offer a new approach for tumor biological diagnosis and tumor treatment. |
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| Keywords: | B7-H4 |
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