p53、MRP表达预测新辅助化疗后ⅢA期非小细胞肺癌患者预后

目的]探讨ⅢA期非小细胞肺癌患者新辅助化疗后p53、MRP蛋白表达水平与患者预后的相关性。方法]检测73例经新辅助化疗的ⅢA期非小细胞肺癌患者术后标本p53、MRP蛋白表达水平。采用Kaplan-Meier法和Log-Rank检验分析生存率，采用Cox模型作多因素分析。结果]新辅助化疗73例患者完全缓解（CR）4例、部分缓解（PR）36例，总有效率为54．79％。73例患者术后3年生存率为35．62％，p53、MRP蛋白表达阴性者术后3年生存率均高于阳性者（P〈0．05）。Cox多因素分析显示p53、MRP蛋白表达水平、淋巴结转移、肿瘤分化程度、化疗疗效与患者预后呈显著性相关。结论]p53、MRP蛋白的表达水平与新辅助化疗患者的预后相关，可以预测化疗疗效．指导临床化疗。

Prognostic Prediction with Expression of p53 and MRP in Patients with Non-small Cell Lung Cancer Stage Ⅲ A after Neoadjuvant Chemotherapy

Propose] To explore the correlation of p53 and MRP expression protein with prognosis in cases with non-small cell lung cancer （NSCLC） stage Ⅲ A after neoadjnvant chemotherapy. Methods]Expression of p53 and MRP protein in 73 cases with stage Ⅲ A NSCLC after neoadjuvant chemotherapy was detected by immunohistochemical method. Kaplan-Meier analysis and Log-Rank test were used to evaluate the survival rates. Cox model was used for multivariate analysis. Resultsl Of 73 cases with NSCLC after neoadjuvant chemotherapy, complete response （CR） was observed in 4 cases, partial response （PR） in 36 cases, the overall response rate was 54.79%.The 3-survival rate postoperation was 35.62% in 73 cases. The 3-survival rate in the cases with p53, MRP positive expression was longer than that with p53, MRP negative expression（P〈0.05）.Muhivariate analysis by Cox model showed that p53 and MRP expression, lymph node metastasis,cancer differentiation and the efficacy of neoadjuvant chemotherapy were significantly correlated with prognosis. Conelution] The expression of p53 and MRP significantly correlated with prognosisin cases with NSCLC stage Ⅲ A after neoadjuvant chemotherapy. It may use to predict the efficacy of neoadjuvant chemotherapy and to guide clinical chemotherapy.