| 长循环脂质体的研究进展及其在核医学中的应用 |
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| 引用本文： | 马超,匡安仁.长循环脂质体的研究进展及其在核医学中的应用[J].生物医学工程学杂志,2007,24(4):941-945. |
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| 作者姓名： | 马超 匡安仁 |
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| 作者单位： | 四川大学,华西医院,核医学科,成都,610041 |
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| 摘 要： | 脂质体作为药物载体具有很多优点,但是其主动靶向性和稳定性较差,聚乙二醇或与配体连接的聚乙二醇修饰的脂质体,即长循环脂质体,具有延长脂质体在血液循环中的半衰期、提高其稳定性、改变脂质体在体内的生物学分布,赋予脂质体靶向性的优点。本文主要综述了长循环脂质体的研究进展及其在核医学中的应用。
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| 关 键 词： | 长循环脂质体 聚乙二醇 靶向性 |
| 修稿时间： | 2004-06-102004-10-20 |
Long Circulation Liposome and Nuclear Medicine |
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| Ma Chao,Kuang Anren.Long Circulation Liposome and Nuclear Medicine[J].Journal of Biomedical Engineering,2007,24(4):941-945. |
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| Authors: | Ma Chao Kuang Anren |
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| Institution: | Department of Nuclear Medicine, West China Hospital,Sichuan University,Chengdu 610041,China |
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| Abstract: | Liposomes play an important role in drug delivery systems. However, conventional liposomes are short of active targeting ability and stability in blood circulation, which is required for efficient drugs delivery of interest. PEGs-containing liposomes are able to be stabilized in blood circulation for a longer period of time,able to be delivered properly in time and in amount to the targeted organs,and able to suppress the side effects of some drugs. |
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| Keywords: | Long circulation liposome(LCL) Polyethylene glycol Targeting property |
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