Delayed adverse reaction to sodium ioxaglic acid-meglumine |
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| Authors: | Kanny G Marie B Hoen B Trechot P Moneret-Vautrin D A |
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| Institution: | Service de Médecine D, Médecine Interne, Immunologie Clinique et Allergologie, CHU de Nancy, H?pital Central, 29, avenue de Lattre-de-Tassigny, 54035 Nancy Cedex, France. g.kanny@chu-nancy.fr |
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| Abstract: | A patient had a maculopapular rash, fever, hepatic cytolysis, rhabdomyolysis, eosinophilia and raised total IgEs after coronarography with ioxaglic acid-meglumine (Hexabrix). Intradermal test to ioxaglic acid-meglumine was positive 48 hrs later. Histological examination revealed perivascular lymphocytic infiltration, with predominantly CD45Ro+ and CD8+ T cells and apoptotic basal keratinocytes. This case documents a late hypersensitivity reaction to ioxaglic acid-meglumine. |
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