缺氧条件下冻伤对大鼠血液凝固系统某些因素的影响

为研究高原冻伤的发病机理及防治措施，探讨了缺氧条件下冻伤大鼠血液凝固系统的变化，将雄性Ｗｉｓｔａｒ大鼠（２００±２０ｇ）随机分为四组，冻后４ｈ－３ｄ测定血液的出血，凝血时间，血块回缩率，前列环素，血栓素含量及Ｔ／Ｐ比值，结果表明，冻伤后各组大鼠出血和凝血时间缩短，血块回缩率降低，血浆中ＰＧＩ２和ＴＸＡ２含量增加，Ｔ／Ｐ比值升高，且缺氧习服冻伤大鼠各项指标的改变尤为明显，提示，冻伤可使血凝系统发生改

Effects of frostbite on some factors of blood coagulation system in rats under hypoxia]

The changes of some factors of blood coagulation system in rats following frost-bite of both hind feet under hypoxia were investigated. Male Wistar rats weighed 200 +/- 20g were divided into four groups: normal control (C); frostbite at normoxia (FN); frostbite during acute hypoxia (FAH) and frostbite during hypoxia after altitude acclimation (FHAC). Bleeding time and clotting time, rate of clot-retraction, plasma content of 6-keto-PGF1 alpha and TXB2 were determined following exposure to cold. The results showed that bleeding time and clotting time were shortened, and rate of clot-retraction was decreased, plasma content of 6-keto-PGF1 alpha and TXB2, T/P ratio were increased significantly after exposure to cold in all frostbite groups, but these changes were more prominent in FHAC than those in FN and FAH. The results demonstrated that there were changes in blood coagulation system following cold injury, blood coagulability was increased. These changes were closely related to the degree of frostbite. In addition, the degree of cold injury was aggravated by altitude acclimation and this may play an important role in the pathological process of dysfunction leading to necrosis of local frostbite tissue.