Efficacy of rituximab in an aggressive form of multicentric Castleman disease associated with immune phenomena |
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Authors: | Ocio Enrique M Sanchez-Guijo Fermin M Diez-Campelo Maria Castilla Cristina Blanco Oscar J Caballero Dolores San Miguel Jesus F |
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Institution: | Servicio de Hematologia, Hospital Universitario de Salamanca, Spain. emocio@usal.es |
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Abstract: | Multicentric Castleman disease (MCD) is an uncommon lymphoproliferative disorder for which the best therapeutic option is not yet well established. Immune-related disorders are rare complications of MCD. We report on an MCD case in a 23-year-old patient with extensive abdominal involvement and associated immune hemolytic anemia and Raynaud phenomenon. He was negative for human immunodeficiency virus (HIV) and human herpesvirus-8 (HHV-8). After 8 courses of the anti-CD20 monoclonal antibody (rituximab), the patient achieved complete remission. Interestingly, Raynaud phenomenon disappeared under treatment and no new hemolytic events occurred. Anti-CD20 antibody treatment could be an attractive therapeutic approach for MCD, mainly when immune-related disorders are associated. |
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Keywords: | multicentric Castleman disease rituximab anti‐CD20 monoclonal antibody immune hemolytic anemia Raynaud phenomenon |
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