白细胞介素-23在结核性脑膜炎早期诊断中的应用价值

目的检测早期结核性脑膜炎患者脑脊液中白细胞介素-23(IL-23)水平,探讨其在结核性脑膜炎发病机制中可能的作用及其临床意义。方法应用双抗体夹心酶联免疫吸附测定法,检测40例早期结核性脑膜炎治疗前以及治疗后以及37例病毒性脑膜炎患者脑脊液中IL-23的水平。结果与病毒性脑膜炎患者相比,结核性脑膜炎患者脑脊液中IL-23水平明显升高(P<0.01),而结核性脑膜炎患者脑脊液中IL-23水平在治疗1周后即明显下降(P<0.01),但仍较病毒性脑膜炎患者水平高(P<0.05)。结论 IL-23水平检测对了解结核病的活动性、判断病情及预后、监测疗效有一定的参考作用。

Application value of detecting interleukin-23 in early diagnosis of tuberculous meningitis

Objective To detect the interleukin-23（IL-23） level of cerebrospinal fluid（CSF） in the patients with tuberculous meningitis before and after therapy,and to investigate its possible role in tuberculous meningitis pathogenesis and clinical significanceMethods Enzyme-linked immunosorbent assay（ELISA） was used to detect the level of IL-23 in CSF of 40 cases of tuberculous meningitis,and 37 cases of virus meningitis.Results The IL-23 level of CSF in tuberculous meningitis was obviously increased compared with that in virus meningitis（P0.01）.Moreover,the IL-23 level was significant decreased in CSF of tuberculous meningitis after treating with anti-tuberculosis for 1 week（P0.01）,but still higher than that in virus meningitis（P0.05）.Conclusion It is suggested that the IL-23 level is helpful to understand the level of disease activity,determine the condition and prognosis,and monitor the treatment efficacy.