急性冠状动脉综合征检测同型半胱氨酸的临床应用

目的 探讨急性冠状动脉综合征(ACS)患者血清同型半胱氨酸(Hcy)水平的变化,以为ACS进的早期预防、治疗提供依据.方法 检测健康对照组与ACS患者的血清Hcy水平,进行统计分析.结果 心肌梗死(AMI)组Hcy浓度高于不稳定型心绞痛(UAP)组(P<0.05),ACS组的Hcy水平高于健康对照组(P<0.01).健康对照组56例中仅有1例Hcy异常,异常检出率为1.8%;ACS组60例中有40例异常,异常检出率为66.7%.ACS组的异常检出率显著高于健康对照组(P<0.01).结论 ACS患者血清Hcy水平明显升高,AMI的血清Hcy水平较UAP的更高,提示Hcy在ACS的发病机制中起重要作用.高Hcy水平是急性冠状动脉综合征的高危险因素之一.

Clinical application of homocysteine detection in patients with acute coronary Syndrome

Objective To explore the change of serum homocysteine（Hcy） level in the patients with acute coronary syndromes（ACS） to provide the basis for early prevention and treatment of ACS.Methods Serum Hcy level in normal control group and the ACD group was detected for statistical analysis.Results The Hcy level in the acute myocardial infarction（AMI） group was higher than that in the unstable angina（UAP） group（P0.05）.The Hcy level in the ACS group was higher than that in the control group（P0.01）.In the normal control group（56 cases）,only 1 case showed abnormal Hcy with the abnormal rate of 1.78%,while in the ACS group（60 cases）,40 cases revealed abnormal Hcy with the abnormal rate of 66.7%.The abnormal rate in the ACS group was significantly higher than that in the normal control group（P0.01）.Conclusion Serum Hcy level in ACS patients is significantly increased,serum Hcy level in AMI is much higher than that in UAP,indicating Hcy plays an important role in the pathogenesis of ACS.High Hcy level is one of high risk factors of ACS.