进展期胃癌浸润浆膜层或邻近器官相关因素分析

目的 探讨进展期胃癌浸润浆膜层或邻近器官与胃癌体积、胃癌分型、胃癌生长部位、胃癌病理学类型及胃癌分化程度等相关因素的关系.方法 收集相关资料完整的进展期胃癌病例876例,对其进行单因素分析,χ2检验.结果 肿瘤直径d≤4 cm时浸润浆膜层或邻近器官(SE+AD)的发生比率(35.14%)与d＞6 cm时(SE+AD为 86.67%)相比较存在显著性差异(P＜0.005).BorrmannⅠ型的SE+AD发生比率最低(32.18%),Ⅳ型最高(82.05%),二者比较时存在显著性差异(P＜0.005),Ⅰ型与Ⅱ型(41.56%)比较时,无显著性差异(P＞0.05),其余各组间比较时存在显著性差异(P＜0.005).胃体部的SE+AD(48.47%)与胃底贲门部(64.23%)、胃窦部(63.10%)分别比较时,存在显著性差异(P＜0.005).乳头状腺癌和管状腺癌的SE+AD发生比率分别为:13.04%和25.26%,印戒细胞癌为87.50%,二部分比较时存在显著性差异(P＜0.005).高分化组的SE+AD(16.67%)与未分化组(86.59%)比较时存在显著性差异(P＜0.005),各组间比较时亦存在显著性差异(P＜0.05).结论 进展期胃癌浸润浆膜层或邻近器官与胃癌体积、胃癌分型、胃癌生长部位、胃癌病理学类型及胃癌分化程度等相关因素均有不同程度的关系.

Analysis of Related Factors Involving the Invasion into Serosal Layer or Adjacent Organs of Advanced Gastric Cancer

Objective To study the correlations between the invasion into serosal layer or adjacent organs of advanced gastric cancer and some related factors such as the size,classification,position,pathology type and grade of the gastric cancer.Methods 876 cases of advanced gastric cancer were collected with detailed information,and the univariate analysis and chi-square test were made.Results The frequency of invasion into serosa or adjacent organs(SE+AD) was 35.14% in advanced gastric cancer with a diameter≤4 cm,which was significantly lower than that(86.67%) in the cancer with a diameter>6cm.In the Borrmann classification,the frequency of type I was the lowest one(32.18%),the frequency of type IV was the highest one(82.05%).There are significant differences between them(P<0.005).When we compared type I with type II,there was no significant difference(P>0.05),and when we compared the rest,there was significant difference in each group(P<0.005).The frequency of(SE+AD) invasion was much lower in gastric body(48.47%) than that in gastric cardia(64.23%) and gastric antrum(63.10%),there were significant differences between them(P<0.005).The frequency of(SE+AD) invasion in papillary adenocarcinoma and tubular adenocarcinoma were 13.04% and 25.26%,which were much lower than that in signet ring cell carcinoma(87.50%).These two parts were significantly different(P<0.005).The frequency of(SE+AD) invasion in well-differentiated group and undifferentiated group were 16.67% and 86.59% respectively,the comparison between them was significantly different(P<0.005).Conclusion There is a certain degree of relationship between the invasion into serosal layer or adjacent organs of advanced gastric cancer,the size,classification,position,pathology type and grade of the gastric cancer.