胆汁返流性胃炎的动物实验与临床观察研究

对１０茶犬作胃一空肠吻合术，建立胆汁返流性胃炎实验模型。可见该模型胃液中胆酸明显高于术前（Ｐ＜０．０１），同时游离酸和Ｎａ＋均有不同程度升高，ｐＨ值降低；胃粘膜表现糜烂、溃疡、炎细胞浸润。作者认为在胆汁返流性胃炎的发病中，胆酸对胃粘膜的破坏起着主要作用，且返流时间与病变程度成正比。结合５８例舰员病例观察研究，结果与动物模型相符，从而证实了本文对胆汁返流性胃炎发病机理的基本论点。

ANIMAL EXPERIMENT AND CLINICAL OBSERVATION ON BILE REFLUX GAS-TRITIS

astrojijunostomy was performed on 10 dogs to establish bile reflux gastritis mod-el.It was found that the gastric trihydroxycholic acid in this model was significantly higher than those before the operation(P<0.01),and the HCl and Na were both in creased in different degrees,whereas the pH was lowered.The gastric mucosa in the model showed erosion,ulcer and inflammatory cell infiltration. The authors hold that the gastric trihydroxycholic acid plays the key role in destroying gastric mucosa in refer-ence to the pathogenetic mechanism of bile reflux gastritis,and the duration of reflux is positively related to the severity of pathological changes.The result of the study of 58 clinical cases is consistent with that of the animal model.