食管癌血清肿瘤标志物诊断价值的研究

为探讨肿瘤标志物联合检测在食管癌诊断中的临床意义，分别用酶免法（EIA）、酶法、高效液相色谱法（HPLC）等测定了49例食管癌及272例非肿瘤患者的29种血清肿瘤标志物，应用特异性、阳性预期值、敏感性、阴性预期值、总有效率、5项平均值6个指标综合评价各种肿瘤标志物的价值。结果29种肿瘤标志物中，平均排序前6位的是糖类抗原242（CA^242)、精眯（SPM）、腐胺（PU）、肿瘤相关物质群（TSGF）、谷胱甘肽转移酶（GST）、角蛋白－19（CYFRA211），TSGF、GST和癌胚抗原（CEA）的敏感性为84．62％。其中前二项敏感性为75．51％，三项中任一项阳性所致的特异性为48．68％。提示TSGF、GST、CEA联合检测对食管癌诊断有实用价值。

Dliagnostic value of serum tumor markers in esophageal cancer

To explore the chonical diagnostic value of combined detection of multipile tumor markers in esophageal cancer.29 types of tumor markers in 49 patients with esophageal cancer were detected by enzyme linked immunosobent assay (ELISA),enzyme methed and highperformance liquid chromatography(HPLC) The clinical diagnostic value of different type of tumor markers were evaluated using specificity,positive expective value,sensitivity,negtive expective value,total valid and averag e value Results showed that in the 29 types of tumor markers,the best six tumor markers of average value were cancer antigen 242(CA242),spermidine (spm),putrescine (pu),tumor supplide group of factors(TSGF),glutathione s-transferase (GST) and cytokeratins(CYFRA-211),the sensitivity of TSGF, GST and cacinoembryonic antigen (CEA) was 84 62%,and the sensitivity of the first two markers among the three was 75 51%,the specificity of one markers positive only among the three waw 48 68%. This sugg ests combined dectection of TSGF,GST and CEA has virtual clinical diagnostic value in esophageal cancer.