甲状腺素对人胚胸腺细胞CD2抗原表达的影响

运用不同剂量甲状腺素与人胚胸腺细胞经不同时间孵育后，检测胸腺细胞Ｅ－玫瑰花环形成率。结果显示，在体外，甲状腺素的量高于血清总Ｔ４生理值５～１００倍时，胸腺细胞Ｅａ成花率明显增高，但无明显的量效关系，同样剂量的甲状腺素对胸腺细胞ＥＴ成花率无明显影响。孵育４ｈ后，加甲状腺素和不加甲状腺素的胸腺细胞Ｅａ成花率明显降低，孵育１６ｈ后，Ｅａ、ＥＴ进一步降低。提示，甲状腺素能促进胸腺细胞ＣＤ２抗原的表达，并可能在胸腺细胞发育过程中具有促进胸腺细胞分化的作用。

Effect of Thyroxine on CD 2 Expression of Human Embryonic Thymocytes

After incubation of thyroxine with human embryonic thymocytes for 1,2,4 and 16 hours,E rosette formation rates were tested.The results showed ,the rated of E a were increased when thyroxine levels were higher 5-100 times than normal physiological level.No effect of ,however,same thyroxine level on E t rates was observed.After incubation for 4 hours,the E a rosette rates were significantly lower,and for 16 hours,the E t rates were decreased with thyroxine or without thyroxine.It suggests that thyroxine may promote CD 2 expression of thymocytes,and have effect on differentiatildn of thymocytes in their development.