Inhibition of forskolin-stimulated adenylate cyclase activity by 5-HT receptor agonists |
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| Authors: | M Devivo S Maayani |
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| Affiliation: | 1. Faculty of Pharmacy, AIMST University, Semeling, Kedah, Malaysia;2. AIMST University, Semeling, Kedah, Malaysia;3. Department of Pharmacy, Shri Venkateshwara University, Gajraula, India;4. Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj, Odisha, India |
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| Abstract: | We measured the inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig hippocampal membranes by 5-HT, 5-carboxamidotryptamine (CAT) and 8-hydroxy-2-(di-n-propylamino) tetralin (PAT). Low concentrations of these agonists inhibited forskolin-stimulated adenylate cyclase activity in a concentration-dependent and saturable manner. The antagonist spiperone shifted the concentration-response curve to CAT to the right in a parallel manner. The EC50 values of CAT, PAT and 5-HT and the KB of spiperone suggest that this receptor may correspond to the 5-HT1A binding site. |
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