高血压脑出血患者血肿中NPY和CGRP对继续出血及脑水肿的影响

目的 探讨高血压脑出血患者脑内血肿中神经肽Y（NPY）与降钙素基因相关肽（CGRP）与脑出血病理变化的关系。方法 采用放射免疫法测定30例脑出血患者脑血肿和外周血浆中NPY与CGRP的含量。结果 血肿与患者血浆NPY和CGRP含量均高于对照组血浆水平。有继续出血者血肿NPY和CGRP含量高于非继续出血者的水平。血肿抽吸后，外周血中含量下降。结论 NPY和CGRP两种物质增多是高血压脑出血继续出血、血肿扩大和脑水肿发生的重要病理机制之一。

A study on NPY and CGRP in hematoma effects on continuing hemorrhage and brain edema in patient with hypertensive cerebral hemorrhage

Objective To investigate the correlation of neuropeptide Y(NPY) and calcitonin gene related peptide(CGRP) in intercerebral hematoma with pathologic change of hypertensive cerebral hemorrhage. Methods The Levels of NPY and CGRP in hematoma and plasma were measured by radioimmunoassay in 30 cases of patients with hypertensive cerebral hemorrhage. Results Compared with the control group,the levels of NPY and CGRP in hematoma and plasma of patients increased significantly. Compared with the non continuing hemorrhagic group,the levels of NPY and CGRP in hematoma of continuing hemorrhage increased signifircantly. The levels of plasma decreased after operation. Conclusion The substances of NPY and CGRP are the major causes of continuing hemorrhage,hematoma enlargement and brain edema.