Giant Cell Myocarditis and Endomyocardial Calcification in a 2.5-Month-Old Infant Triggered by Excessive Maternal Alcohol Abuse: Case Study of an Unusual Association |
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Authors: | Jozef Krajcovic Martin Janik Katarina Adamicova Lubomír Straka Frantisek Stuller Frantisek Novomesky |
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Institution: | 1. Institute of Forensic Medicine and Medicolegal Expertises, Jessenius Faculty of Medicine, Comenius University, University Hospital, 036 59, Martin, Slovak Republic 2. Institute of Anatomic Pathology, Jessenius Faculty of Medicine, Comenius University, University Hospital, Martin, Slovak Republic
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Abstract: | This report describes an unusual case of a 2.5-month-old infant’s sudden death secondary to giant cell myocarditis and endomyocardial calcification, both unusual entities in pediatric patients. The mother had a history of excessive alcohol consumption during pregnancy and the postnatal period. No infectious etiologies, hypersensivity, or autoimmune disorders were identified. Therefore, the authors assume that alcohol exposure might be responsible for the inflammatory giant cell process complicated with endomyocardial calcification in susceptible infants. This report is the first to describe the rare form of noninfectious myocarditis complicated with endomyocardial calcification possibly triggered by a toxic agent. The authors discuss the possible interaction between these processes that led to the infant’s sudden death. |
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