| 3,4-二酰氧基苯骈吡喃类化合物的合成及生物活性 |
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| 引用本文： | 颜铮,黄文龙,彭司勋,华维一. 3,4-二酰氧基苯骈吡喃类化合物的合成及生物活性[J]. 药学学报, 1997, 32(2): 97-105 |
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| 作者姓名： | 颜铮 黄文龙 彭司勋 华维一 |
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| 作者单位： | 中国药科大学药化研究室，上海有机化学研究所 |
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| 摘 要： | 苯骈吡喃类钾通道启开剂为研究高血压药物开辟了新途径。前胡丙素具有类似结构，为寻找活性高毒副作用小的降压药物，结合二者结构特征，设计合成了２４个３，４－二酰氧基苯骈吡喃类化合物，药理初筛表明某些化合物有一定程度的降压活性。
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| 关 键 词： | 钾通道启开剂 苯骈吡喃类 降压活性 |
| 收稿时间： | 1995-11-20 |
SYNTHESIS AND BIOACTIVITY OF SOME 3,4-DIACYLOXYBENZOPYRANS |
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| Z Yan,WL Huang,SX Peng and WY Hua. SYNTHESIS AND BIOACTIVITY OF SOME 3,4-DIACYLOXYBENZOPYRANS[J]. Acta pharmaceutica Sinica, 1997, 32(2): 97-105 |
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| Authors: | Z Yan WL Huang SX Peng WY Hua |
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| Affiliation: | Division of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009. |
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| Abstract: | Considerable attention is now being given to the potassium channel openers of benzopyrans as potential therapeutical agents for hypertension. In order to search for novel antihypertensive with high efficacy and low toxicity, integrating structural features of cromakalim and praeruptorin C, twenty four compounds of 3,4 diacyloxybenzopyrans were designed and synthesized. Some of them exhibited hypotensive activity in Sprague Dawley rats. |
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| Keywords: | Benzopyrans Potassium channel openers Hypotensive activity |
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