Expression patterns of natriuretic peptides in pre-hibernating and hibernating anatolian ground squirrel (Spermophilus xanthoprymnus) lung |
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Authors: | Mustafa Öztop Mehmet Özbek Narin Liman Feyzullah Beyaz Emel Ergün Levent Ergün Ural Kemal Kavraal Ergül Ergen |
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Institution: | 1. Department of Biology, Faculty of Science and Art, Mehmet Akif Ersoy University, Burdur, Turkey;2. Department of Histology and Embryology, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University, Burdur, Turkey;3. Department of Histology and Embryology, Faculty of Veterinary Medicine, Erciyes University, Kayseri, Turkey;4. Department of Histology and Embryology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey |
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Abstract: | Anatolian ground squirrel (Spermophilus xanthoprymnus) is a true hibernator. This animal transiently reduces pulmonary function during hibernation. Continuance of pulmonary function is very important to survive ground squirrels during the hibernation. Natriuretic peptides may be key players in the modulation of pulmonary hemostasis. However, NPs’ role in pulmonary function during hibernation remains unclear. We aimed to investigate the localization and distribution of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) in squirrel lungs during pre-hibernation and hibernation periods using immunohistochemistry. Our immunohistochemical data indicate that ANP, BNP, and CNP were produced by the mucosal epithelium of terminal and respiratory bronchioles, smooth muscle cells in the lamina propria of terminal bronchioles and vascular smooth muscle cells, alveolar type II cells, and macrophages. ANP immunoreactivity was weaker than BNP and CNP immunoreactivities in these cells. The results also demonstrate that the number of ANP, BNP and CNP positive alveolar type II cells tended to increase, although statistically non-significant, during the hibernation period, but the expression of NPs in other pulmonary cells is unaffected by hibernation. This study firstly investigates ANP, BNP and CNP distribution in the Anatolian ground squirrel lung. However, further studies are required to dissect their functional roles during the hibernation. |
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Keywords: | Corresponding author at: Mustafa ÖZTOP Department of Biology Faculty of Science and Art Mehmet Akif Ersoy University Burdur 15030 Turkey Anatolian ground squirrel Hibernation Natriuretic peptides Lung |
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