Organ Transplantation From Nonstandard Risk Donors: Midway Between Rigid and Flexible Rules |
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Authors: | Carlo Petrini Silvia Trapani Luciana Riva Giovanna Floridia Sabina Gainotti Letizia Lombardini Lucia Masiero Lucia Rizzato Alessandro Nanni Costa |
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Affiliation: | 1. Unità di Bioetica, Istituto Superiore di Sanità, via Giano della Bella, Rome, Italy;2. Comitato Nazionale per la Bioetica, Presidenza del Consiglio dei Ministri, via della Mercede, Rome, Italy;3. Centro Nazionale Trapianti, Istituto Superiore di Sanità, via Giano della Bella, Italy |
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Abstract: | In order to bridge the gap between available organs and patients needing transplants, donor selection criteria for donors are increasingly being extended; the possibility of using organs from nonstandard risk donors has been introduced in many countries. This clearly poses considerable ethical issues that should be analyzed and taken into consideration by the competent bodies and institutions. In this article, we illustrate the Italian situation regarding the possibility of using organs from anti-hepatitis C virus (HCV) and HCV RNA-positive donors (anti-HCV+ve) in negative recipients (healthy subjects who have never come into contact with the hepatitis C virus) in light of the availability of new direct-acting antiviral drugs (DAAs) for hepatitis C treatment. We discuss the motivations behind the both favorable opinions of the Ethics Committee of the Italian National Institute of Health (Istituto Superiore di Sanità) and the Italian National Bioethics Committee (Comitato Nazionale per la Bioetica) discussing the main implications from an ethical point of view. |
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Keywords: | Address correspondence to Carlo Petrini Istituto Superiore di Sanità (Italian National Institute of Health), Via Giano della Bella 34, 00162 Rome, Italy. Tel: ++39 06 4990 4021 Fax: ++ 39 06 4990 4303. |
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