Long-Term Outcomes of Renal Function After Adult Intestinal Transplantation at a Single Small-Volume Center: 2 Cases of Renal Transplantation |
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Authors: | Kyung Jai Ko Hye Kyung Chang Su-Kyung Kwon Young Hwa Kim Mi-Hyeong Kim Kang Woong Jun Jae Woo Park Kyung Hye Kwon Jeong Kye Hwang Sang Dong Kim Sun Cheol Park Jae Hee Chung Ji Il Kim Sang Il Kim Myung-Duk Lee In Sung Moon |
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Affiliation: | 1. Department of Surgery, Kangdong Sacred Heart Hospital, Seoul, Republic of Korea;2. Department of Surgery, Kyunghee University Hospital, The Kyunghee University of Korea, Seoul, Republic of Korea;3. Department of Surgery, Seoul St. Mary''s Hospital, The Catholic University of Korea, Seoul, Republic of Korea;4. Department of Surgery, Daejeon St. Mary''s Hospital, The Catholic University of Korea, Daejeon, Republic of Korea;5. Department of Surgery, Eunpyeong St. Mary''s Hospital, The Catholic University of Korea, Seoul, Republic of Korea;6. Department of Surgery, Bucheon St. Mary''s Hospital, The Catholic University of Korea, Gyeonggi, Republic of Korea;7. Department of Surgery, Incheon St. Mary''s Hospital, The Catholic University of Korea, Incheon, Republic of Korea;8. Department of Surgery, Uijeongbu St. Mary''s Hospital, The Catholic University of Korea, Gyeonggi, Republic of Korea;9. Department of Internal Medicine, Seoul St. Mary''s Hospital, The Catholic University of Korea, Seoul, Republic of Korea;10. Department of Surgery, Yeouido St. Mary''s Hospital, The Catholic University of Korea, Seoul, Republic of Korea |
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Abstract: | PurposeRenal dysfunction more frequently occurs after intestinal transplantation (ITx) than after heart, lung, or liver transplantation. We provide a clinical analysis of renal function after adult ITx.MethodsWe retrospectively analyzed 8 adult ITx patients who survived for at least 6 months between 2004 and 2018. Glomerular filtration rate (GFR) measurements were performed at baseline, at 3 and 6 months post-transplantation, and yearly. The median follow-up duration was 53.5 months.ResultsAll cases were isolated ITx; 3 received living-donor ITx, and 5 received deceased-donor ITx. The mean baseline GFR was 97 mL/min/1.73 m2. The GFR had decreased by more than 50% of baseline at 1 year post-transplant. Renal dysfunction was observed in 4 patients. Two patients developed acute kidney injury due to acute rejection and sepsis. One of these patients fully recovered renal function, but the second patient died. Another 2 patients developed chronic kidney disease and required hemodialysis (HD) within 6 and 3 years, respectively. The first living-donor ITx patient lost renal function progressively over 6 years after ITx. She received a renal graft from the same living donor as for the ITx after 3 years of HD. The other patient (deceased-donor ITx) received a kidney from his daughter at 5 months after HD.ConclusionsTo obtain an accurate assessment of renal function, frequent direct measurements of GFR should be performed to facilitate early diagnosis of renal impairment and to determine subsequent strategies to improve renal function after ITx. |
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Keywords: | Address correspondence to Jeong Kye Hwang, MD, PhD, Department of Surgery, Daejeon St. Mary's Hospital, College of Medicine, the Catholic University of Korea, 64 Daeheung-ro, Jung-gu, Daejeon, 34943, Republic of Korea. Tel: 82-42-220-9235 Fax: 82-42-220-9565. |
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