Simvastatin Alleviates Intestinal Ischemia/Reperfusion Injury by Modulating Omi/HtrA2 Signaling Pathways |
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| Authors: | Ying Yan Xiaoni Lv Jun Ma Ganji Hong Shikai Li Jiahao Shen Haotian Chen Kailei Cao Senjiang Chen Tao Cheng Chaojie Dong Jiahui Han Heng Ma Mingkang Wu Xin Wang Chenkai Xing Yutao Zhu Lanyu Shen Zhongchao Wang |
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| Affiliation: | 1. Department of Rehabilitation Medicine, Zhejiang Chinese Medical University, The Third Clinical Medicine, Hangzhou, Zhejiang, China;2. Department of Trauma Surgery, Army 952 Hospital of the Chinese People’s Liberation Army, Geermu, Qinghai, China;3. Grade 2016, Clinical Medicine, Jiaxing University Medical College, Jiaxing, ZJ, PR China;4. Department of Neurology, The First Affiliated Hospital, Xiamen University, Xiamen, China;5. Department of Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, Fujian, China;6. Department of Pathology and Pathophysiology, Provincial Key Discipline of Pharmacology, Jiaxing University Medical College, Jiaxing, China;7. Cardiovascular Medicine, Shanxi Cardiovascular Disease Hospital, Taiyuan, Shanxi, China |
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| Abstract: | PurposeThe objective of this research was to survey the therapeutic action of simvastatin (Sim) on intestinal ischemia/reperfusion injury (II/RI) by modulating Omi/HtrA2 signaling pathways.MethodsSprague Dawley rats were pretreated with 40 mg/kg Sim and then subjected to 1 hour of ischemia and 3 hours of reperfusion. The blood and intestinal tissues were collected, pathologic injury was observed, the contents of serum tumor necrosis factor-α and interleukin–6 (IL–6) were estimated, and superoxide dismutase, methane dicarboxylic aldehyde, and cysteinyl aspartate specific proteinase–3 (caspase–3) levels, as well as the expressions of Omi/HtrA2 and caspase–3, were measured in the intestinal tissues.ResultsSim preconditioning mitigated the damnification of intestinal tissues by decreasing oxidative stress, inflammatory damage, and apoptosis and downregulating the expression of Omi/HtrA2 compared to the ischemia/reperfusion group, while Sim+Ucf–101 significantly augmented this effect.ConclusionThese results suggest that Sim may alleviate intestinal ischemia/reperfusion injury by modulating Omi/HtrA2 signaling pathways. |
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| Keywords: | Address correspondence to Fei Tong Department of Xiamen Cardiovascular Hospital Xiamen University Xiamen Fujian China. |
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