心肌营养素1血浆水平对慢性心力衰竭诊断的临床价值研究

目的探讨检测心肌营养素1(CT-1)血浆水平对慢性心力衰竭(CHF)诊断的临床价值。方法选择74例CHF患者作为病例组,按NYHA心功能分级分组:心功能Ⅱ级24例,心功能Ⅲ28例,心功能Ⅳ22例。25例健康体检者作为对照组。对所有的研究对象用酶标免疫分析方法测定血浆CT-1浓度,酶联免疫吸附法测定脑钠肽(BNP)血浆浓度,分析CT-1和BNP血浆浓度与CHF心功能的关系。结果病例组血浆CT-1和BNP浓度明显高于对照组,病例组血浆CT-1和BNP浓度随着NYHA分级增高而逐级升高,差异有统计学意义(P<0.01)。CT-1和BNP血浆浓度与左心室射血分数呈负相关性(CT-1:r=-0.755;BNP:r=-0.684,均P<0.01)。结论血浆CT-1浓度可能是反映CHF严重程度的指标。联合测定CT-1和BNP血浆浓度对CHF的早期筛查诊断具有重要的临床价值。

The Clinical Diagnostic Value of Testing Plasma Cardiotrophin-1 in Patients with Chronic Heart Failure

Objective To investigate the clinical value of detection of plasma levels of cardiotrophin-1(CT-1)for the diagnosis of chronic heart failure.Methods 74 cases of patients with chronic heart failure(CHF)were recruited as the case group,according to the NYHA classification of cardic function,class Ⅱ 24 cases;class Ⅲ 28 cases;class Ⅳ 22 cases;25 healthy cases were selected as control group.All the research objects were tested plasma CT-1 concentration by enzyme immunoassay,plasma levels of BNP were determined by immune fluorescence.Results The plasma CT-1 and BNP concentrations of case group were significantly higher than those in the control group.The plasma CT-1and BNP concentrationsincreased along with NYHA grade increase,the differences were significant(P<0.01).CT-1 and BNP plasma concentrations and left ventricular ejection fraction(LVEF)were negatively correlated(CT-1:r=-0.755;BNP:r=-0.684,P<0.01).Conclusion CT-1 plasma concentration may be an index to reflectCHF severity.Combined determination of CT-1 and BNP plasma concentrations has important clinical value in CHF early diagnosis.