A new antibiotic, okicenone. I. Taxonomy, fermentation, isolation and biological characteristics |
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| Authors: | K Komiyama S Funayama Y Anraku M Ishibashi Y Takahashi T Kawakami S Omura |
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| Affiliation: | Kitasato Institute, Tokyo, Japan. |
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| Abstract: | A new antibiotic, okicenone was isolated from the culture broth of Streptomyces sp. KO-3599. The antibiotic possesses cytocidal activity against mammalian tumor cells in vitro at concentrations of 0.53-11.0 micrograms/ml whereas the antibiotic showed no antimicrobial activities against Gram-positive and Gram-negative bacteria, fungi or yeast at a concentration of 1,000 micrograms/ml. |
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