奥沙利铂为主的联合化疗结合同步放疗治疗晚期大肠癌的疗效观察

目的评价奥沙利铂联合氟尿嘧啶、亚叶酸钙结合放疗治疗晚期大肠癌的临床疗效。方法现察组28例，奥沙利铂（L—OHP）130mg／m^2，静滴2h，d1；亚叶酸钙（CF）100mg／m^2静滴lh，d1-5；氟尿嘧啶（5一Fu）500mg／m^2静滴4h，d1～5，21d为1周期。对照组36例，亚叶酸钙（CF）100mg／m^2静滴1h，d1～5；氟尿嘧啶（5一Fu）500mg／m^2静滴4h，d1～5，共化疗4周期。均同步放疗，全盆腔照射，总量50～60Gy／20～30F／5～6周。结果观察组近期疗效完全缓解（PR）4例，部分缓解（CR）14例，总有效率64．3％，1年生存率为71．4％，对照组近期疗效完全缓解（PR）2例，部分缓解（CR）10例，总有效率33．3％，1年生存率为58．3％，主要毒副作用如消化道反应，放射性直肠炎，骨髓抑制现察组比对照组明显减轻。而神经毒性观察组比对照组稍重。结论奥沙利铂为主的联合化疗方案结合同步放疗治疗晚期大肠癌效果好，喜副作用小。

OXALIPIAFION AND FLUROURACIL IN COMBINATION WITH CONCURRENT RADIOTHERAPY FOR ADVANCED COLORECTAL CANCER

Objective To evaluate the effect of oxaliplation(LOHP)+flurouracil calcium folinate(5-FU CF)incombination with concurrent radiotherapy in advanced colorectal cancer and to find a more effective way of administration.Methods There were 28 patients in observation group,who were treated with chemotherapy: L-OHP 130mg m2,iv infusion for 2 hours in day 1,combined with calcium folinate 100mg m2 for 1 hours followed by 5-fluorouracil 350mg m2 for 4h,which were repeated for 3 weeks from day l to day 5.Radiotherapy: whole pelvic irradiation DT 50 ~60 Gy 20~30F 5~6 weeks.There were 36 cases in control group.Chemotherapy: calcium folinate 100mg m2 for 1 hour followed by 5-fluorouracil 350 mg m2 for 4h,from day l to day 5,which was repeated every 3 weeks.Radiotherapy: whole pelvic irradiation DT 50 ~60Gy 20~30F 5~6weeks. Results 64 advanced colorectal cancer patients all entered the study.For the observation group,4 patient reached complete response(CR),14 partial response(PR).The overall response rate(CR+PR) was 64.3%,the 1 year survival rate was 71.4%.For the control group,2 patient reached complete response(CR),10 partial responsed(PR),The overall response rate(CR+PR) was 33.3%, the 1 year survival rate was 58.3%.The main adverse acute effects,such as gastrointestinitis,anemia and irradiation rectitis,bone mallow suppression,the observation group was fewer than the control group,but neurosensory toxicity was reverse.Conclusions Oxalipiafion and flurouracil in combination with concurrent radiotherapy could improve the therapeutic effect on advanced colorectal cancer.