Quantitative and sustained suppression of renal sympathetic nerve activity by left atrial distension in conscious dogs |
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Authors: | Kenju Miki Yoshiaki Hayashida Keizo Shiraki |
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Institution: | (1) Departments of Physiology and Systems Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807 Kitakyushu, Japan |
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Abstract: | In order to investigate the interrelations between left atrial pressure (Pla) and renal sympathetic nerve activity (RSNA) and heart rate (HR), Pla was increased by a balloon both in conscious sham-operated and cardiac-denervated dogs. RSNA was decreased and HR was increased with increasing Pla in sham-operated dogs. The reflex changes in RSNA and HR induced by the stimulation of atrial receptors persisted for at least 15 min. There was a consistent relationship between Pla and RSNA which could be described by a single exponential equation: % RSNA = 80.0(1–e–0.395 Pla), or by a linear equation when Pla was less than 6 mmHg; % RSNA=-13.5 Pla–2.25. The relationship between Pla and HR can be described by a single exponential equation: HR = 86.5(1–e–0.125 Pla). A significant linear relationship between RSNA and HR was obtained during a graded left atrial distention (% RSNA=-1.08 HR–17.7). In cardiac-denervated dogs, RSNA tended to increase and HR remained constant during the left atrial distention. These results indicate that left atrial receptors regulate RSNA and HR in both a quantitative and sustained manner in conscious sham-operated dogs. |
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Keywords: | Atrial mechanoreceptors Cardiac denervation Heart rate Body fluid regulation Conscious dog |
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