Activation of Membrane-Bound Adenylate Cyclase by Glucagon in Neurospora crassa |
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| Authors: | Mirtha M. Flawiá and Héctor N. Torres |
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| Affiliation: | Instituto de Investigaciones Bioquímicas “Fundación Campomar” and Facultad de Ciencias Exactas y Naturales, Obligado 2490, Buenos Aires 28, Argentina |
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| Abstract: | Membrane-bound adenylate cyclase in Neurospora crassa is activated by glucagon. Half-maximal effect is observed at hormone concentrations of about 10 nM. After solubilization of the enzyme with Lubrol-PX, the glucagon effect is lost. Incubation of neurospora cells with glucagon leads to a decrease in the activity of glycogen synthetase (EC 2.4.1.11) and to an increase in the activity of glycogen phosphorylase (EC 2.4.1.1) and in the rate of glycogenolysis. |
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