性激素在肝癌发生中作用的动物实验

目的 探讨性激素在大鼠肝癌发生中的作用.方法 将大鼠80只随机分成四组:第一组为对照组,饮常水,正常喂食;其余3组饮含二乙基亚硝胺(DENA)水,自由饮用,液体隔日更换,14周后停用DENA,改饮常水,在3组中分别加服用已烯雌酚、甲睾酮和甲孕酮,观察每组肝癌发生情况.结果 雌激素组、雄激素组和孕激素组肝癌发生率分别为:30%、85%和55%,3组肝癌发生率具有显著性差异(P<0.05).雌激素组第18周仍有大部分为肝硬化.而雄激素组第12周即部分大鼠已经出现肝癌,第16～18周的均已经癌变.孕激素组介于上述两组之间.结论 雌激素在大鼠肝癌的发生中具有较强抑制作用,是一个保护因子;孕激素在肝癌的发生中起抑制作用,是一个保护因子;肝癌是一个雄激素依赖性肿瘤,雄激素在肝癌的发生中起促进作用,是一个危险因子.但是三种激素均不是诱发肝癌独立因素或主要因素.

Animal experiments of the role of sex hormones in the liver cancer

Objective To study effect of sex hormones in the development of rat hepatocellular carcinoma Methods 80 rats were randomly divided into four groups: the first group was the control group,drank mineral water,ate normal feeding,the other 3 groups drank water containing DENA,liquid after was replaced,after 14 weeks DENA was stopped and drank mineral water,in the 3 group were added with diethylstilbestrol,testosterone and armor progesterone respectively,the hepatocellular carcinoma incidence in each group was observed.Results Estrogen,androgen and progesterone group the incidence of liver cancer are: 30%,85% and55% respectively,three groups of liver cancer incidence rate had significant difference(P< 0.05).Most of estrogen group still were cirrhosis of the liver in the eighteenth week.However,part rats had appeared liver cancer in the 12th weeks,16 to 18 weeks were cancerous in androgen group.Progesterone group was between the two groups.Conclusion Estrogen in rat liver tumors have stronger inhibition is a protective factor;Progesterone in liver tumors inhibition plays,is a protective factor,Liver cancer is a androgen dependence tumor,androgen in liver tumors contribute in,is a risk factors.But the three types of hormones are not induce lier cancer independent factors or main factors.