单纯性肥胖儿童血清瘦素等相关激素的监测与分析

目的:研究单纯性肥胖儿童血液中瘦素、胰岛素、甲状腺素、生长激素的浓度水平变化及其与肥胖发生发展的关系。方法:以10～15岁的肥胖和正常对照儿童各40例为研究对象,以放射免疫法测定血中的瘦素、胰岛素、甲状腺素、生长激素水平。结果:肥胖组儿童血清瘦素和胰岛素水平均显著高于正常儿童(P<0.01),而生长激素水平显著低于对照组(P<0.01),T3水平明显高于正常儿童(P<0.01),T4水平变化不明显。结论:肥胖儿童存在瘦素抵抗及内分泌紊乱,瘦素、胰岛素、甲状腺素在儿童肥胖的发生发展过程中,起着一定的促进作用,而肥胖导致生长激素减少,影响儿童的生长发育。

Monitoring and analysis on related hormones such as leptin and so on in children of simple obesity

Objective:To study the change of leptin,insulin,thyroxine and growth hormone contents in blood and their relation with the development of children's simple obesity.Methods:40 normal children and 40 simple obesity children aged 10～15 years old were investigated.The contents of leptin,insulin,thyroxine and growth hormone were detected by radioimmunoassay.Results:The contents of leptin,insulin in simple obesity children were significantly higher than those in normal children(P<0.01),the content of growth hormone in simple obesity children was significantly lower than that in normal children(P<0.01).The content of T3 in simple obesity children was significantly higher than that in normal children(P<0.01).There was no significantly difference in the content of T4 between simple obesity children and normal children.Conclusion:There are counteraction to leptin and endocrine disturbance in obesity children.Leptin,insulin,thyroxine can promote the development of children's obesity.Obesity leads to the decrease of growth hormone,which affects the growth and development of children.