Survivin和HSG/MFN2在卵巢癌中的表达及其意义

目的:探讨Survivin和HSG/MFN2在卵巢癌发生、发展过程中的作用及意义。方法:用免疫组化法检测Sur-vivin和HSG/MFN2在不同卵巢组织中的表达情况。结果:①Survivin阳性染色主要位于细胞核,呈棕黄色颗粒,正常卵巢组织、良性卵巢肿瘤、恶性卵巢癌组,Survivin的阳性表达率分别为3.3%、13.3%和60.0%;与正常卵巢组织和良性卵巢肿瘤组比较,恶性卵巢癌组Survivin表达率呈上升趋势,差异均有统计学意义(P<0.05)。②HSG/MFN2阳性染色主要位于细胞浆,呈棕黄色颗粒,正常卵巢组织、良性卵巢肿瘤、恶性卵巢癌组,HSG/MFN2的阳性表达率分别为43.3%、46.7%和73.3%;与正常卵巢组织和良性卵巢肿瘤组比较,恶性卵巢癌组HSG/MFN2表达率呈上升趋势,差异均有统计学意义(P<0.05)。结论:Survivin和HSG/MFN2在恶性卵巢癌组织中表达上调,与卵巢癌淋巴结转移和临床病理分期密切相关。

Expression and significance of survivin and HSG/MFN2 in patients with ovarian Cancers

Objective:To explore the function and significance of survivin and HSG/MFN2 in the course of carcinogenesis and growth of ovarian cancers.Methods:Survivin and HSG/MFN2 were detected in different tissues of ovaries by immunohistochemistry staining.Results:①The positive staning of survivin was yellow or yellow-brown grains which were located mainly in karyoplast.The positive rates of survivin in normal ovarian tissues,benign ovarian tumors and malignant ovarian cancers were 3.3%,13.3% and 60.0%,respectively,the positive rate of survivin in malignant ovarian cancer group was significantly higher than those in normal ovarian tissue group and benign ovarian tumor group(P<0.05).②The positive staning of HSG/MFN2 were yellow brown grains which were located mainly in cytoplasm.The positive rates of HSG/MFN2 in normal ovarian tissues,benign ovarian tumors and malignant ovarian cancers were 43.3%,46.7% and 73.3%,respectively,the positive rate of HSG/MFN2 in malignant ovarian cancer group was significantly higher than those in normal ovarian tissue group and benign ovarian tumor group(P<0.05).Conclusion:Up-regulation of survivin and HSG/MFN2 in malignant ovarian cancer group is closely related to lymphatic metastasis and clinical pathologic stages.