小儿过敏性咳嗽与肺炎支原体感染的相关性探讨

目的:探讨小儿过敏性咳嗽与肺炎支原体(MP)感染的关系及大环内酯类药物治疗的效果。方法:选择我院儿科门诊及住院的过敏性咳嗽患儿89例为观察组,99例同期就诊、年龄相仿的急性上呼吸道感染患儿为对照组A,以及儿童保健科正常体检小儿86例为对照组B。3组患儿均应用颗粒凝集法测定MP-IgM。观察组MP-IgM阳性者应用阿奇霉素治疗。结果:观察组MP-IgM阳性率为40.4%;对照组AMP-IgM阳性率为12.1%;对照组BMP-IgM阳性率为8.1%。36例过敏性咳嗽并MP感染的患儿在常规哮喘治疗基础上,加用阿奇霉素口服,总有效率为83.3%。随访6～12个月,仅4例轻度咳嗽发作。结论:小儿过敏性咳嗽与肺炎支原体感染关系密切,过敏性咳嗽并MP感染的患儿在常规治疗基础上加用大环内酯类药物疗效明显。

Investigation on correlation between allergic cough and mycoplasma pneumoniae infection in children

Objective:To explore the correlation between allergic cough and mycoplasma pneumoniae(MP)in children and the effect of macrolide treatment.Methods:89 children with allergic cough were selected as observation group,99 children with acute upper respiratory tract infection and 86 healthy children were selected as control group A and control group B.The levels of MP-IgM in three groups were detected by particle agglutination method.Children in observation group with positive MP-IgM were treated by azithromycin.Results:The positive rates of MP-IgM in observation group,control group A and control group B were 40.4%,12.1% and 8.1%,respectively.the total effective rate of azithromycin in 36 children of allergic cough was 83.3%,only four children of mild cough attack after 6~12 follow-up.Conclusion:The pediatric allergic cough is related to mycoplasma pneumoniae infection,conventional therapy plus macrolide drugs is effective.