| 80例生育异常患者染色体核型分析 |
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| 引用本文： | 郭航,许秉乙,高元奇,李哲,许宗革,刘睿智.80例生育异常患者染色体核型分析[J].中国妇幼保健,2009,24(11). |
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| 作者姓名： | 郭航 许秉乙 高元奇 李哲 许宗革 刘睿智 |
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| 作者单位： | 1. 吉林大学第二医院泌尿外科,吉林,长春,130041
2. 吉林大学白求恩医学院细胞生物学教研室·吉林省生殖医学研究所 |
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| 基金项目： | 人口及优牛优育技术研究及应用项目 |
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| 摘 要： | 目的:探讨染色体核型异常与生育异常的关系。方法:对2004年5月～2008年5月到吉林省生殖医学研究所临床基地进行遗传咨询的2 485例患者进行外周血淋巴细胞培养和染色体核型分析。结果:2 485例患者中,染色体核型异常患者257例,异常率为10.34%。在染色体异常核型中,性染色体异常154例,占59.92%;常染色体异常103例,占40.08%。结论:生育异常与染色体核型异常有着密切的关系,对生育异常患者进行染色体核型分析,有利于临床诊断,也可为遗传咨询提供依据。
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| 关 键 词： | 染色体核型 流产 无精/少弱精子症 |
Analysis on chromosome karyotypes in 80 cases of abnormal fertility |
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| Abstract: | Objective:To explore the relationship between abnormal karyotypes and abnormal fertility.Methods:2 485 genetic counseling patients in the Institute for Reproductive Medicine of Jilin province were investigated from May 2004 to May 2008,whose peripheral blood lymphocytes were cultured and the abnormal karyotypes were analyzed.Results:257 cases(10.34%) of abnormal karyotypes were found in 2 485 patients,including 154 cases(59.92%) of sex chromosome abnormalities and 103 cases(40.08%) of euchromosome abnormalities.Conclusion:Abnormal karyotype is closely related to abnormal fertility,karyotype analysis is conducive to clinical diagnosis,also provides the basis for genetic counseling. |
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| Keywords: | Chromosome karyotype Abortion Azoospermia |
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