早产儿脑室周围白质软化临床高危因素分析

目的:探讨早产儿脑室周围白质软化(PVL)发生的高危因素。方法:对2005年1月1日～2007年7月1日入住我院新生儿一科确诊为PVL的早产儿42例(PVL组)和无PVL的早产儿40例(对照组)进行回顾性分析。结果:PVL组与对照组危险因素的单因素分析表明:两组新生儿胎膜早破、窒息、感染、酸中毒、入院1 h动脉氧分压、入院3天内动脉二氧化碳分压、机械通气时间有显著性差异。多因素logistic回归分析表明胎膜早破、窒息、感染、低氧血症和低碳酸血症是PVL的主要危险因素。结论:胎膜早破、窒息、感染、酸中毒、机械通气时间、低氧血症和低碳酸血症是早产儿PVL的高危因素。

Analysis on clinical high risk factors for periventricular leukomalacia in preterm infants

Objective:The explore the high risk factors for periventricular leukomalacia(PVL) in preterm infants.Methods:A retrospective analysis was carried out on 42 preterm infants with PVL and 40 preterm infants without PVL from January 1,2005 to July 1,2007.Results:There was significant difference in premature rupture of membranes(PROM),asphyxia,infection,acidosis,PaO2(within the first 24 hours of hospitalization),PaCO2(within the first 3 days of hospitalization) and mechanical ventilation between PVL group and control group.The main risk factors for PVL were PROM,asphyxia,infection,hypoxemia and hypocapnia indicated by the logistic regression analysis.Conclusion:PROM,asphyxia,infection,hypoxemia,hypocapnia are high risk factors for preterm infants with PVL.