| 非小细胞肺癌长春瑞滨加顺铂方案化疗敏感性与XPC基因多态性及单体型的关系 |
| |
| 引用本文： | 翟雅娜,徐倩,洪成雨,张晔,袁媛.非小细胞肺癌长春瑞滨加顺铂方案化疗敏感性与XPC基因多态性及单体型的关系[J].辽宁医学杂志,2011,25(4):177-183. |
| |
| 作者姓名： | 翟雅娜 徐倩 洪成雨 张晔 袁媛 |
| |
| 作者单位： | 中国医科大学附属第一医院肿瘤研究所,110001 |
| |
| 摘 要： | 目的基因多态预测肿瘤化疗药物敏感性对肿瘤个体化治疗具有重要意义,本文旨在探讨DNA修复基因XPC多态性及单体型对非小细胞肺癌（NSCLC）长春瑞滨加顺铂（NP）方案化疗敏感性的影响。方法 采用聚合酶链反应-限制性片段长度多态性技术检测163例NSCLC患者DNA修复基因XPC多态性及单体型;选择NP方案化疗,化疗2个周期后评价疗效,并分析化疗敏感性与XPC基因多态性的关系。结果与XPC Val499A la多态C/C基因型者相比,C/T＋T/T基因型的NSCLC患者化疗敏感性增大到2.166倍（P=0.048,OR=1.008-4.655）;与携带XPC PAT多态L等位基因者相比,携带S等位基因的个体化疗敏感性增大到2.353倍（P=0.034,OR=1.047-5.291）;以其他单体型者为参照,携带XPC C-L-A（Val499A la-PAT-Lys939G ln）单体型的个体在化疗无效组的比率（6.7%）显著高于有效组（0.0%）,差异有显著性（P=0.007）。结论携带XPC C-L-A（Val499A la、PAT、Lys939G ln）单体型患者对NP方案化疗应答差,XPC基因位点多态性对NSCLCNP方案化疗敏感性具有较好的预测作用。
|
| 关 键 词： | DNA修复基因XPC 多态性 非小细胞肺癌 NP方案 化疗敏感性 |
The correlation of the sensitivity to NP chemotherapy in non-small lung cancer to DNA repair gene XPC polymorphism |
| |
| Zhai Yana,Xu Qian,Hong Chengyu,et al..The correlation of the sensitivity to NP chemotherapy in non-small lung cancer to DNA repair gene XPC polymorphism[J].Medical Journal of Liaoning,2011,25(4):177-183. |
| |
| Authors: | Zhai Yana Xu Qian Hong Chengyu |
| |
| Institution: | Zhai Yana,Xu Qian,Hong Chengyu,et al.Department Cancer Institute,First Affiliated Hospital of China Medical University.Shenyang 110001,China |
| |
| Abstract: | Objective Selecting patients according to key genetic polymorphisms may help to optimize the treatment in tumor individualized treatment.Polymorphisms at the xeroderma pigmentosum group C(XPC) gene have been associated with alterations in DNA repair and may change sensitivity to the patients of non-small cell lung cancer(NSCLC) used vinorelbine plus cisplatin(NP) chemotherapy.Methods 163 patients with NSCLC taking NP chemotherapy drugs were evaluated according to the efficacy of the treatment.We used polyme... |
| |
| Keywords: | XPC polymorphism non-small cell lung cancer NP chemotherapy chemotherapy sensitivity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
