FADD在卵巢癌中的表达及其临床意义

目的:研究Fas相关死亡域蛋白(FADD)在卵巢癌中的表达,探讨其在卵巢癌发生、发展中的作用及临床意义,并判断卵巢癌的恶性程度、估计其预后。方法:采用SP免疫组织化学方法检测62例卵巢癌、15例卵巢良性肿瘤和16例正常卵巢组织中FADD的表达,并分析卵巢癌的临床病理资料。结果:①正常卵巢组织中FADD阳性表达率为87.5%,卵巢良性肿瘤阳性表达率为73.3%,卵巢癌阳性表达率为32.3%,正常卵巢与卵巢癌中的阳性表达率差异有高度显著性(P<0.01),卵巢良性肿瘤与卵巢癌中的阳性表达率差异亦有高度显著性(P<0.01),而正常卵巢与卵巢良性肿瘤的阳性表达率差异无显著性(P>0.05)。②各组标本中FADD的表达阳性程度较低,并以弱阳性为主(共36例),阳性共11例,强阳性标本数为0。③FADD的阳性表达率在Ⅰ期、Ⅱ期及Ⅲ期和Ⅳ期合并组间比较有显著性差异(P<0.05);FADD的阳性表达率与临床分期呈负相关(P<0.001)。④中分化组与低分化组的FADD的阳性表达明显低于高分化组,差异有高度显著性(P<0.01)。⑤浆液性囊腺癌阳性表达率为31.8%;非浆液性囊腺癌阳性表达率为33.3%。两组FADD的表达无显著性(P>0.05)。结论:FADD在卵巢癌的发生发展中起着重要的作用,根据其表达率的高低可以判断肿瘤的恶性程度,估计卵巢癌的预后,为基因水平治疗卵巢癌提供新的思路。

Clinical significance and expressions of FADD in ovarian cancer

Objective:To study FADD expression in ovarian cancer,discuss its function and clinical significance in occurrence and development of ovarian cancer,judge malignant degree and estimate prognosis.Methods:The expression of FADD were detected in immunohistochemical method in 62 cases of ovarian cancer,15 cases of benign tumor and 16 cases of normal tissue.To analyze clinical pathological data of ovary cancer.Results:①Positive expression rate of FADD was 87.5%.and 73.3% and 32.3% in normal ovarian tissue and in ovarian benign tumor and in ovarian cancer respectively.There was significance in the positive expression rate between normal ovarian tissue and ovarian cancer(P<0.01).It was also significant between ovarian benign tumor and ovarian cancer(P<0.01).While it was not significant between normal ovarian tissue and ovarian benign tumor(P>0.05).②Each specimen positive expression rate was low and regard weak positive as principle(36 cases),middle positive 11cases,strong positive 0 case.③There was obvious difference of FADD positive expression rates in four FIGO stage(P<0.05).In addition FADD positive expression rate is negative to clinical analysis(P<0.001).④The rates in moderately differentiation and poorly differentiation were evidently lower than that in well-differentiation.The difference was significant.⑤The positive rate in serous cystadenocarcinoma was 31.8 % and 33.3% in non-serous cystadenocarcinoma respectively.The difference between them was not evident(P>0.05).Conclusion:FADD play an important part in the occurrence and development of ovarian cancer.We judge malignant degree of the tumor and estimate ovarian cancer prognosis on the basis of positive expression rate.FADD will provide new way of future gene therapy for ovarian cancer.