葡萄膜黑色素瘤的表观遗传学研究进展

表观遗传学指不改变DNA排列次序而改变基因或染色体最终表型的现象,其异常表现在肿瘤的发生发展中起着重要作用.葡萄膜黑色素瘤是成年人眼病患者中最常见的原发眼内恶性肿瘤,从表观遗传学的角度研究其病因和发病机制是目前一个新的研究方向.研究发现DNA的甲基化、组蛋白修饰和微小RNA的异常表达可能与葡萄膜黑色素瘤的发生相关联,这些发现可能为葡萄膜黑色素瘤的早期诊断、治疗和预后预测提供新的可能性.

Progress of epigenetic research on uveal melanoma

Epigenetics refers to the study of heritable changes in gene function or chromosome expression that occur without a change in the sequence of the DNA.The abnormal epigenetic expression plays an important role in the tumor development.Uveal melanoma is the most common intraocular malignant tumor in adults.The emerging emphasis on epigenetic mechanisms in the studies of this disease represents a new research direction.Relevant researches show that the abnormal epigenetic expression of DNA,such as methylation,histone modification,and miRNA misexpression may have some type of correlational relationships with the development of uveal melanoma.These findings may provide new possibilities for early diagnosis,treatment,and sequela prevention of uveal melanoma.