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充血性心力衰竭患儿血清甲状腺激素水平的变化及意义
引用本文:陈谱,林郁生,吴北燕. 充血性心力衰竭患儿血清甲状腺激素水平的变化及意义[J]. 广东医学, 2000, 21(9): 742-743
作者姓名:陈谱  林郁生  吴北燕
作者单位:汕头大学医学院第一附属医院儿科(515041)
基金项目:广东省医药卫生青年科学研究基金!资助 (课题序号1 9970 90 )
摘    要:目的 探讨小儿充血性心务衰竭(CHF,简称心衰)时血清甲状腺激素水平的变化及意义。方法 用放射免疫法分别测定62例CHF患儿心衰急性期、恢复期及36例正常对照组血清三碘甲状腺原氨酸(T3)、四碘 甲状腺原氨酸(T4)、促甲 腺激素(TSH)、反三碘甲状腺原氨酸(rT#)及T3与rT3的比值(T3/rT#)。结果 CHF组急性期与对照组比较:T3明显下降,P〈0.05;rT3显著升高、T3/rT3显

关 键 词:充血性心力衰竭 甲状腺激素 儿童 CHF
修稿时间:2000-02-02

Change and significance of serum thyroid hormone in children with congestive heart failure
CHEN Pu,Lin Yusheng,WuBeiyan. Change and significance of serum thyroid hormone in children with congestive heart failure[J]. Guangdong Medical Journal, 2000, 21(9): 742-743
Authors:CHEN Pu  Lin Yusheng  WuBeiyan
Affiliation:Chen Pu,Lin Yusheng,Wu Beiyan. Department of Pediatrics,First Affiliated Hospital,Shantou University Medical College,Shantou 515041
Abstract:Objective To study the change and significance of serum thyroid hormone in children with congestive heart failure(CHF).Methods Serum triiodothyronine(T 3), tetraiodothyronine(T 4), thyroid stimulating hormone(TSH), reverse T 3(rT 3) levels, and the ratio of T 3/rT 3 were detected with immunoradiometric assay in 62 CHF patients at the acute stage and recovery stage, and in 36 normal children, respectively.Results In the acute stage of CHF, the serum T 3,T 3/rT 3 decreased and rT 3 increased significantly( P <0 01) than in control group, but T 4 and TSH were not significantly different from controls. The more serious the CHF, The lower T 3, T 3/rT 3 levels, and the higher rT 3 levels ( P <0 01).In addition, T 4 decreased significantly in the serious CHF patients ( P <0 01) and did not change in the mildor moderate CHF patients. In the recovery stage, T 3 and T 3/rT 3 increased significantly ( P <0 05, P <0 01) and rT 3 decreased significantly ( P <0 01).Conclusion In the acute stage of CHF, serum T 3, T 3/rT 3 decrease and rT 3 increase, while T 4 does not change in the severe patients. The determination of serum thyroid hormone is important in studying the pathogenesis of CHF and estimating prognosis.
Keywords:Heart failure   congestive Thyroid hormone Children
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