p53蛋白表达对不同部位大肠癌患者预后判断的价值

目的　探讨p5 3蛋白过度表达对不同部位大肠癌患者预后判断的价值。方法　应用免疫组化方法检测 75例大肠癌组织中 p5 3蛋白表达情况。 结果　p5 3蛋白表达阳性率为 46.7% (3 5 / 75 )。远侧大肠癌 p5 3蛋白表达率 (5 9.5 % )显著高于近侧者(3 0 .3 % ) (P <0 .0 5 )。p5 3蛋白表达与其它临床病理因素无明显相关。全组中位数随访时间为 60个月 ,p5 3蛋白表达阳性与阴性患者术后总生存率比较有显著性差异 (P <0 .0 5 )。在远侧大肠癌组织中 p5 3阳性患者的预后明显差 (P <0 .0 1)。而在近侧大肠癌中 ,2组患者的预后则无显著性差异 (P >0 .0 5 )。结论　不同部位大肠癌 p5 3蛋白表达存在一定差异 ,p5 3蛋白过度表达对远侧大肠癌患者预后判断有重要作用

Prognostic Value of p53 Expression in Colorectal Cancer at Different Location

Objective To explore the prognostic value of p53 expression in patients with colorectal cancer at different location.Methods p53 protein was detected by immunohistochemistry in tumor tissue specimens from 75 primary colorectal adenocarcinomas.Results Of 75 samples,35(46.7%) had positive expression of p53.p53 overexpression was more frequently existed in distal-located tumor than in proximal-located tumor(59.5% vs.30.3%,P<0.05).There was no correlation between p53 expression and other clinicopathologial variables.Median follow-up duration was 60 months.Patients with p53-positive tumors showed a lower overall survival rate than those with p53-negative tumors(P<0.05).Furthermore,in patients with distal-located colorectal cancer,p53-positive patients had significantly poor prognosis,compared with p53-negative patients(P<0.01),but in patients with proximal-located colon cancer,prognosis was not different(P>0.05).Conclusion The overexpression of p53 protein is influenced by the the tumor location.It may provide important prognostic information in distal-located colorectal cancer.