393例抗癫痫药物血药浓度监测结果分析

目的通过分析该院抗癫痫药物血药浓度监测分析的结果,为临床合理用药提供参考。方法运用高效液相色谱法,对丙戊酸钠、苯妥英钠、卡马西平、苯巴比妥在393例病人中的血药浓度进行测定,并对结果进行统计分析。结果丙戊酸钠(50～100 mg.L-1)、卡马西平(4～12 mg.L-1)、苯妥英钠(10～20 mg.L-1)、苯巴比妥(15～40 mg.L-1)在有效血药浓度范围内的例数分别为:111例(76.55%)9、3例(77.50%)、41例(73.21%)、52例(72.22%)。结论抗癫痫药物血药浓度监测结果显示,临床用药应综合考虑各方面因素,实施个体化给药方案,确保用药安全有效。

Concentration monitoring results of serum antiepileptic drugs in 393 cases

Objective To decribe the monitoring data of blood concentration of antiepileptic drugs, and to provide the evidence for clinical rational drug use. Methods High performance liquid chromatography was used to test the concentration of valproate, phenytoin, carbamazepine, phenobarbital sodium pod in blood. Results The numbers of patients with effective concentration of sodium valproate, carbamazepine, phenytoin, phenobarbital sodium were 111,93, 41,52, respectively. Conclusion Clinicians should consider the use of drugs comprehensively, and make personalized medicine scheme to improve rational drug use.