高血压病合并抑郁状态与轻度认知功能障碍相关性研究

目的研究高血压病合并抑郁状态与轻度认知功能障碍的关系。方法首次诊断为高血压病患者120例,根据汉密尔顿抑郁量表(HAMD)评分结果分为高血压伴抑郁组和非抑郁组各60例,采用蒙特利尔认知评估量表(MoCA)评价其认知功能。结果伴抑郁组为MoCA(22.6±2.1)分,非抑郁组(28.7±1.2)分,两组比较差异有显著性,P<0.05。伴抑郁组轻度认知功能障碍37例,且HAMD评分与MoCA评分呈负相关r,=-0.67,P<0.05,非抑郁组轻度认知功能障碍11例,明显低于伴抑郁组,经卡方检验,P<0.05。结论高血压病合并抑郁状态与轻度认知功能障碍有关,抑郁状态严重患者其认知功能障碍越严重。

Relationship between depression after hypertension and mild cognitive impairment

Objective To study the relationship between depression and mild cognitive impairment. Methods One hundreds and twenty patients with a diagnosis of hypertension were included in the study and were divided into depression group and non-depression group by Hamilton depression rating scale （HAMD）. Cognitive impairment was determined by MoCA. Results MoCA was 22.6 ± 2.1 in depression group and 28.7 ± 1.2 in non-depression group. There was negative correlation between HAMD and MoCA. There was significant difference between two group,P 〈 0.05. There were thirty-seven patients with mild cognitive impairment in depression group and eleven in nondepression group, Conclusion Depression status of patients with hypertension is related with mild cognitive impairment. The more obvious the depression, the more serious the cognitive impairment.