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Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats. |
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| Authors: | Y Yoshiyama S Nishikawa T Sugiyama T Kobayashi H Shimada F Tomonaga S Ohdo N Ogawa S Nakano |
| Abstract: | Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminoglycosides. |
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