| 急性心肌梗死患者IL-8及一氧化氮的变化和意义 |
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| 引用本文： | 冯武,余跃. 急性心肌梗死患者IL-8及一氧化氮的变化和意义[J]. 医学理论与实践, 2005, 18(8): 875-877 |
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| 作者姓名： | 冯武 余跃 |
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| 作者单位： | 1. 十五冶职工医院内科,湖北黄石,435000
2. 华中科技大学协和医院内科教研室 |
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| 摘 要： | 目的:探讨急性心肌梗死(AMI)患者血清白细胞介素-8(IL-8)及一氧化氮(NO)的水平变化及意义。方法:选择住院的AMI患者36例、不稳定性心绞痛(UA)患者28例及正常对照者24例,分别应用酶联免疫法和改良Griess法测定周围血中IL-8、NO的水平。结果:AMI患者IL-8水平明显高于UA组及正常对照组,各组IL-8变化依次为AMI组>UA组>正常组,且AMI患者血清IL-8水平随心功能KillipI~IV级呈递增趋势,尤以IV级为甚(P<0·001);NO浓度则呈相反变化。结论:IL-8、NO参与了心肌缺血损伤的发生、发展过程。
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| 关 键 词： | 急性心肌梗死 白细胞介素-8 一氧化氮 |
| 文章编号： | 1001-7585（2005）08-0875-03 |
| 收稿时间： | 2005-03-19 |
| 修稿时间： | 2005-03-19 |
Change of lnterleuldn - 8 and Nitric Oxide in Acute Myocardial Infarction and its Clinic Significance. |
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| FENG Wu,YU Yue. Change of lnterleuldn - 8 and Nitric Oxide in Acute Myocardial Infarction and its Clinic Significance.[J]. The Journal of Medical Theory and Practice, 2005, 18(8): 875-877 |
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| Authors: | FENG Wu YU Yue |
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| Abstract: | Objective: To investigate Changes of interleukin-8 and nitric oxide in acute myocardial infarction(AMI) and its clinic significance.Methods: The serum levels of IL-8、NO in the patients with AMI(n=36)and unstable angina(UA,n=28)were measured by ELISA and modified Griess assay.Meantime 24 healthy subjects were selected as the controls. Results:Levels of IL-8 in AMI group was higher markedly than that of UA group(P<0.01), and levels IL-8 in UA group were also more higher than that of control group (P<0.01).Levels of IL-8 in AMI group were closely associated with the Killip’s grades about cardiac function. But the changes of NO were opposite to IL-8 among the three groups.Conclusion: IL-8、NO may be involved in the pathophysilology of AMI. |
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| Keywords: | Acute myocardial infarction Interleukin-8 Nitric oxide. |
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