剖宫产对新生儿出生后3d内肠道双歧杆菌和乳酸杆菌定植的影响

目的 探讨剖宫产对新生儿出生后3 d内肠道细菌定植的影响.方法 以83例足月新生儿为研究对象,均为配方奶喂养,分为剖宫产组(n=44),自然分娩组(n=39).采集生出后3 d内每天的粪便标本,通过real-time PCR技术对新生儿粪便中的双歧杆菌属,乳酸杆菌属进行定量检测.结果 日龄1、2、3 d剖宫产组粪便标本中双歧杆菌数量的对数值(lg copies/g)分别为5.65±0.64、6.36±1.00、6.69±1.06,自然分娩组分别为5.69±0.75、7.19±1.15、7.49±1.29;日龄1、2、3 d剖宫产组粪便标本中乳酸杆菌数量的对数值分别为4.66±0.73、4.71

Impact of cesarean section delivery on intestinal bifidobacteria and lactobacillius in newborn babies in the first three days after delivery

Objective To investigate the effect of cesarean section delivery on the development of gut microflora in neonates in the first 3days of life.Methods Eighty tree cases of healthy formula-fed term infants were enrolled in the study and divided into two group: vaginal delivery group(n=39) and cesarean section delivery group(n=44).The faecal bifidobacteria and lactobacillius of neonates were consecutively quantified by real-time polymerse chain assays during the first 3 days after birth.Results Bifidobacteria logarithmic absolute value(lg copies/g)of the first three days after birth were 5.65±0.64,6.36±1.00,6.69±1.06 in cesarean section group respectively and 5.69±0.75,7.19±1.15,7.49±1.29 in vaginal delivery group.Lactobacillius logarithmic absolute value(lg copies/g) of the first three days after birth were 4.66±0.73,4.71±0.84,5.16±0.55 in cesarean section group respectively and 5.88±0.41,6.30±0.99,5.79±0.33 in vaginal delivery group.The above value had statistical difference between group to group in different time(P<0.05).Conclusion Cesarean section decrease significantly the count of primary intestinal bifidobacteria and lactobacillius in formula-fed term infants.