危重病患者早期血浆NT-proBNP水平与疾病严重程度及预后的研究

目的 探讨危重病患者血浆N-末端前体脑钠肽(NT-proBNP)表达对其对预后的影响.方法 对46例入住该院ICU的危重病患者,于入科第1天检测血浆中NT-proBNP水平,并行APACHEⅡ评分,根据28 d存活情况,分为生存组和死亡组.根据不同APACHEⅡ评分分值,分为小于15分、15～25分、>25分组.结果 APACHEⅡ评分15～25分组NT-proBNP水平明显高于小于15分组(P<0.05),>25分组NT-proBNP水平明显高于15～25分组(P<0.05);NT-proBNP水平与APACHEⅡ评分显著相关(r=0.658,P<0.01);与生存组比较,死亡组血浆NT-p

Study on relationship between plasma NT- proBNT level with disease severity and prognosis in critical patients

Objective To investigate the influence of plasma N-terminal pro-B-type natriuretic peptide(NT-proBNP) level on the prognosis in the critical patients.Methods 46 critical patients admitted to intensive care unit(ICU) in our hospital were detected the NT-proBNP level on 1 d and performed the acute physiology and chronic health evaluation(APACHEⅡ).According to 28 d survival status,the patients were divided into the survival group and the death group.According to the APACHEⅡ scores,the patients were divided into three groups:<15,15-25 and >25 points.Results The NT-proBNP level in the 15-25 points groups was significantly higher than that in the <15 points group(P<0.05),and the NT-proBNP level in the >25 group was significantly higher than that in the 15-25 points group(P<0.05).The plasma NT-proBNP level was significantly correlated with APACHEⅡscores in the critical patients(r=0.658,P<0.01).Compared with the survival group,the plasma NT-proBNP levels and APACHEⅡ scores in the death group were significantly increased(P<0.05).Conclusion The early increase of plasma NT-proBNP level implies the poor prognosis in the critical patients,which has certain value to judge prognosis.