239例老年非肠道疾病患者肠道菌群状况研究

目的了解重庆市不同年龄和不同病种非肠道老年疾病患者菌群变化规律,探索老年疾病与肠道菌群的关系。方法选取重庆市239例确诊主要3种非肠道老年疾病患者,观察大便培养中6种主要的肠道细菌变化,同时与50例非老年疾病患者进行对照。结果在肠道菌群(肠杆菌、肠球菌、拟杆菌、双歧杆菌、乳杆菌、梭杆菌)中,老年疾病患者与非老年病患者比较除双歧菌外其余差异无统计学意义(P>0.05);而老年糖尿病患者与非糖尿病,双歧杆菌、乳杆菌以及双歧杆菌与肠杆菌的比值(B/E值)显著下降(P<0.05),肠杆菌明显增多(P<0.05);而不同年龄段的老年人中,70～89岁B/E值显著下降(P<0.05)。结论肠道菌群中,双歧菌、乳杆菌和肠杆菌与老年糖尿病和老年年龄有关。

Research on the intestinal flora of the 239 patients in the elderly non-intestinal diseases

Objective To learn the changing rules of the parenteral diseases flora of the old ages at different age and different diseases.Besides,survery the relations between the geriatric diseases and the intestinal floras.Methods Chose 239 diagnosed elderly parenteral diease patients of 3 kinds and observe the main enteric bacterium′changes,then compared to 50 non-elderly patients.Results For the Intestinal floras(the enterobacter,the enterococcuses,the bacteroids,the bifidobacteriums,the lactobacillus,the fusobacteriums),compared the geriatric patients with the non geriatric patients,the coronary heart disease with non coronary heart disease patients,the respiratory with non respiratory patients,the enterobacterias showed no significant difference(P>0.05);But the B/E ratio of the elderly and non-elderly diabetes mellitus patients,that of bifidobacteriums and the lactobacillus,the ratio between the bifidobacteriums and the enterobacters were decreasing obviously(P<0.05);the B/E was decreasing significantly in the 70-89 ages(P<0.05).Conclusion The bifidobacteriums,the lactobacillus and the enterobacters are related to the elderly diabetes mellitus and the olders′ life.