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| 新疆昌吉维吾尔族17个Y-STR基因座遗传多态性 | |
| 引用本文： | 张丽萍,陈健刚,蒲红伟,付志敏,杨昊.新疆昌吉维吾尔族17个Y-STR基因座遗传多态性[J].重庆医学,2012,41(20):2012-2014. |
| 作者姓名： | 张丽萍 陈健刚 蒲红伟 付志敏 杨昊 |
| 作者单位： | 1. 新疆医科大学生物化学与分子生物学教研室,乌鲁木齐,830054 2. 新疆公安厅物证鉴定中心,乌鲁木齐,830006 3. 新疆医科大学高职学院中心实验室,乌鲁木齐,830054 |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | 目的调查17个Y染色体短串联重复序列(Y-STR)基因座及其单倍型在新疆昌吉地区维吾尔族人群中的分布情况。方法采用AmpFlSTR YfilerTM荧光标记复合扩增系统,对154名维吾尔族无关男性个体血样进行17个Y-STR位点的复合扩增,用ABI 3130XL遗传分析仪对扩增产物进行检测分析。结果DYS456、DYS389Ⅰ、DYS390、DYS389Ⅱ、DYS458、DYS19、DYS385a/b、DYS393、DYS391、DYS439、DYS635、DYS392、Y-GATA-H4、DYS437、DYS438、DYS448各位点遗传多样性(GD值)分布在0.529 7～0.959 9之间;17个Y-STR位点共观察到单倍型151种,其单倍型多样性GD值为0.999 7。结论新疆昌吉地区维吾尔族17个Y-STR位点具有丰富的遗传多样性,可为父权鉴定和父系进化研究提供有价值的遗传学资料。 |
| 关 键 词： | Y染色体 STR 维吾尔族 遗传多态性 |
Genetic polymorphisms of seventeen Y-chromosomeal STR loci in XinJiang Changji Uygur Population |
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| Zhang Liping , Chen Jiangang , Pu Hongwei , Fu Zhimin , Yang Hao.Genetic polymorphisms of seventeen Y-chromosomeal STR loci in XinJiang Changji Uygur Population[J].Chongqing Medical Journal,2012,41(20):2012-2014. | |
| Authors: | Zhang Liping Chen Jiangang Pu Hongwei Fu Zhimin Yang Hao |
| Institution: | 1.Department of Biochemistry and Molecular Biology,Xinjiang Medical University,Urumqi,Xinjiang 830054,China; 2.Department of Central Laboraotory,Higher Vocational College,Xinjiang Medical University,Urumqi,Xinjiang 830054, China;3.Xinjiang Public Security Department,Criminal Science&Technology Institute,Urumqi,Xinjiang 830006,China) |
| Abstract: | Objective To investigate the allelic and haplotype frequency distribution of seventeen short tandem repeat loci of Y chromosome in Xinjiang Uygur population in Changji.Methods Seventeen Y-STR loci of which the template DNAs were extracted from blood samples of 154 unrelated male individuals in Uygur population,were amplified by using the AmpFlSTR YfilerTM.The PCR products were analyzed and genotyped with ABI3130XL Sequencer.Results The gene diversity ranged from 0.529 7 to 0.959 9 at DYS456,DYS389Ⅰ,DYS390,DYS389Ⅱ,DYS458,DYS19,DYS385a/b,DYS393,DYS391,DYS439,DYS635,DYS392,Y-GATA-H4,DYS437,DYS438,and DYS448.A total of 151 different haplotypes were observed.The haplotype diversity value calculated from all 17 loci was 0.999 7.Conclusion The 17th Y-STR loci in Xinjiang Uygur population in Changji are highly affluent genetic polymorphic and can offer valuable genetic datas for paternity testing and paternal genetic lineages evolution. |
| Keywords: | Y chromosome short tandem repeat Uygur genetic polymorphism |
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