浙江省台州市接受抗病毒治疗的艾滋病患者生存分析

目的了解浙江省台州市2004—2012年接受抗病毒治疗的艾滋病患者生存状况，并探讨其生存时间影响因素。方法采用回顾性队列研究，对2004—2012年台州市所有≥15岁、接受抗病毒治疗且入组治疗时CD4细胞计数≤350个／mm。的艾滋病患者进行分析。结果共有650例艾滋病患者纳入本次研究。平均发病年龄为（39．0±13．5）岁，其中男性465例（71．5％），男女比例为2．51：1，感染途径以异性传播为主；抗病毒治疗后第12、24、36、48个月的累计生存率分别为0．96、0．95、0．94和0．92。多因素COX回归分析显示：年龄、传播途径、初始治疗方案及入组治疗时CD4细胞水平与研究对象的生存时间存在统计学关联。结论应继续扩大艾滋病筛查的数量和范围，以期早发现，早治疗，延长其生存时间。

Survival analysis of HIV/AIDS patients receiving antiretroviral treatment in Taizhou City of Zhejiang Province,China

Objective To determine the survival rate of HIV/AIDS patients who received free antiretroviral treatment in 2004 -2012 in Taizhou City and the factors associated with survival status. Methods A retrospective cohort analysis was conducted on all the HIV/AIDS patients aged over 15 years who started antiretroviral treatment in 2004 -2012. Results A total of 650 HIV/AIDS patients received antiretroviral treatment during the study period, the mean age was （39. 0 ± 13.5） yeas and 71.5% were males. The ratio of male to female was 2. 51 ： 1. The major transmitted route was heterosexual. The cumulative survival rate of antiretroviral treatment after 12, 24, 36 and 48 months were 0. 96, 0. 95, 0. 94 and 0.92 respectively. Data from the COX proportional hazard regression model analysis indicated that age, transmitted route, initial therapy schedule and CD4 cell counts at baseline were associated with survival time of patients. Conclusions Keeping on enlarging the number and range of AIDS screening is important. Early detection and early treatment of HIV/ AIDS can prolong the survival of HIV/AIDS patients.