Clinical correlation of the CLSI susceptibility breakpoint for piperacillin- tazobactam against extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella species |
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| Authors: | Gavin Patrick J Suseno Mira T Thomson Richard B Gaydos J Michael Pierson Carl L Halstead Diane C Aslanzadeh Jaber Brecher Stephen Rotstein Coleman Brossette Stephen E Peterson Lance R |
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| Affiliation: | Evanston Northwestern Healthcare, IL 60201, USA. pgavin@enh.org |
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| Abstract: | We assessed infections caused by extended-spectrum-beta-lactamase-producing Escherichia coli or Klebsiella spp. treated with piperacillin-tazobactam to determine if the susceptibility breakpoint predicts outcome. Treatment was successful in 10 of 11 nonurinary infections from susceptible strains and in 2 of 6 infections with MICs of >16/4 mug/ml. All six urinary infections responded to treatment regardless of susceptibility. |
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