| 四氢小檗红碱的化学拆分研究 |
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| 引用本文： | 张海峰,薛玲静,童家勇,张灿. 四氢小檗红碱的化学拆分研究[J]. 药学进展, 2010, 34(10): 459-462. DOI: 10.3969/j.issn.1001-5094.2010.10.006 |
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| 作者姓名： | 张海峰 薛玲静 童家勇 张灿 |
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| 作者单位： | 中国药科大学新药研究中心,江苏,南京,210009 |
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| 摘 要： | 目的：通过化学拆分法获得四氢小檗红碱的2种光学异构体。方法：以盐酸小檗碱为原料制备（±）-四氢小檗红碱,以（＋）-二对甲苯甲酰酒石酸为拆分剂在95%乙醇中对其进行拆分。结果：拆分所得的2种四氢小檗红碱异构体旋光值与文献报道一致。结论：通过化学拆分法成功获得了（＋）-和（-）-四氢小檗红碱。
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| 关 键 词： | （±）-四氢小檗红碱 （＋）-二对甲苯甲酰酒石酸 拆分 |
Study on the Chemical Resolution of Tetrahydroberberrubine |
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| ZHANG Hai-feng,XUE Ling-jing,TONG Jia-yong,ZHANG Can. Study on the Chemical Resolution of Tetrahydroberberrubine[J]. Progress in Pharmaceutical Sciences, 2010, 34(10): 459-462. DOI: 10.3969/j.issn.1001-5094.2010.10.006 |
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| Authors: | ZHANG Hai-feng XUE Ling-jing TONG Jia-yong ZHANG Can |
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| Affiliation: | (Center for Drug Discovery, China Pharmaceutical University, Nanjing 210009, China) |
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| Abstract: | Objective： To obtain （＋）-tetrahydroberberrubine and （-）-tetrahydroberberrubine by chemical resolution of （ ± ）-tetrahydroberberrubine. Methods： Tetrahydroberberrubine was synthesized from berberine. Both of the enantiomers were obtained through the classical resolution by using （ ＋ ） -di-p- toluoyl-L-tartarie acid in 95 % ethanol. Results： The optical rotation value of both isomers was as same as that of the literature report. Conclusion： Both of the enantiomers were suceessfully obtained in enantio- merically pure form through chemical resolution. |
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| Keywords: | （ ± ） -tetrahydroberberrubine （ ＋ ） -di-p-toluoyl-L-tartaric acid resolution |
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