Alpha-adrenergic activity of N,N-dimethyldopamine (DMDA). |
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| Authors: | J M Kitzen M Ilhan J G Cannon J P Long |
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| Affiliation: | Department of Pharmacology, College of Medicine and Division of Medicinal Chemistry and Natural Products, College of Pharmacy University of Iowa, Iowa City, Iowa 52242, U.S.A. |
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| Abstract: | The autonomic and cardiovascular activity of N,N-dimethyldopamine (DMDA) was studied in the dog and rabbit. DMDA appears to be a postganglionic sympathetic alpha-adrenoceptor agonist since it consistently caused vasconstriction in several isolated vascular beds, even in the presence of ganglionic blockade. The pressor activity of DMDA was attenuated by the alpha-adrenergic antagonist phentolamine. Calculated pA2 values for phentolamine against both DMDA and norepinephrine in isolated rabbit arteries were in close agreement. DMDA inhibits cardioaccelerator nerve stimulation induced chronotropic responses by a mechanism which appears to be alpha-adrenergic in the dog. |
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| Keywords: | Sympathetic nervous system N,N-Dimethyldopamine Dopamine α-Adrenoceptor Adrenergic inhibition |
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